TargetMol

Lycopodine

Product Code:
 
TAR-T13764
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
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Further Information

Bioactivity:
Lycopodine inhibits proliferation of HeLa cells through induction of apoptosis via caspase-3 activation. Lycopodine, a pharmacologically important bioactive component derived from Lycopodium clavatumspores, triggers apoptosis by modulating 5-lipoxygenase, and depolarizing mitochondrial membrane potential in refractory prostate cancer cells without modulating p53 activity.
CAS:
466-61-5
Formula:
C16H25NO
Molecular Weight:
247.382
Pathway:
Apoptosis; Proteases/Proteasome; Metabolism
Purity:
0.98
SMILES:
[H][C@]12C[C@@H](C)C[C@]34N(CCC[C@]3([H])C(=O)C1)CCC[C@]24[H]
Target:
Lipoxygenase; Caspase

References

1. Bishayee K, et al. Lycopodine triggers apoptosis by modulating 5-lipoxygenase, and depolarizing mitochondrial membrane potential in androgen sensitive and refractory prostate cancer cells without modulating p53 activity: signaling cascade and drug-DNA interaction. Eur J Pharmacol. 2013 Jan 5;698(1-3):110-21. 2. Mandal SK, et al. Lycopodine from Lycopodium clavatum extract inhibits proliferation of HeLa cells through induction of apoptosis via caspase-3 activation. Eur J Pharmacol. 2010 Jan 25;626(2-3):115-22.