TargetMol

AGN194204

Product Code:
 
TAR-T14145
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T14145-5mg5mg£703.00
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TAR-T14145-50mg50mg£1,982.00
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Quantity:
TAR-T14145-100mg100mg£2,560.00
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This product comes from: United States.
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Further Information

Bioactivity:
AGN194204 (IRX4204) is inactive against RAR and is an orally active and selective RXR agonist with Kd values 0.4 nM, 3.6 nM and 3.8 nM and EC50s of 0.2 nM, 0.8 nM and 0.08 nM for RXRα, RXRβ and RXRγ, respectively. AGN194204 has anti-inflammatory and anticarcinogenic actions[1][2].
CAS:
220619-73-8
Formula:
C24H32O2
Molecular Weight:
352.518
Purity:
0.98
SMILES:
CC(C=C[C@@H]1C[C@]1(C)c1ccc2c(c1)C(C)(C)CCC2(C)C)=C/C(O)=O

References

1. Liby K, et al. A new rexinoid, NRX194204, prevents carcinogenesis in both the lung and mammary gland. Clin Cancer Res. 2007 Oct 15;13(20):6237-43. 2. Vuligonda V, et al. Enantioselective syntheses of potent retinoid X receptor ligands: differential biological activities of individual antipodes. J Med Chem. 2001 Jul 5;44(14):2298-303.