TargetMol

β-NETA

Product Code:
 
TAR-T14194
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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Further Information

Bioactivity:
α-NETA is a stable, noncompetitive, slowly reversible choline acetyltransferase (ChAT) inhibitor with an IC50 of 9 μM and is a potent chemokine-like receptor-1 (CMKLR1) antagonist. α-NETA has anti-cancer activity[1][2]. α-NETA weakly inhibits cholinesterase (IC50=84 ?M) and acetylcholinesterase (IC50=300 ?M).
CAS:
31059-54-8
Formula:
C16H20INO
Molecular Weight:
369.246
Pathway:
Neuroscience
Purity:
0.98
SMILES:
[I-].C[N+](C)(C)CCC(=O)c1ccc2ccccc2c1
Target:
AChE

References

1. Sastry BV, et al. Relationships between chemical structure and inhibition of choline acetyltransferase by 2-(alpha-naphthoyl)ethyltrimethylammonium and related compounds. Pharmacol Res Commun. 1988 Sep;20(9):751-71. 2. Graham KL, et al. A novel CMKLR1 small molecule antagonist suppresses CNS autoimmune inflammatory disease. PLoS One. 2014 Dec 1;9(12):e112925. 3. Qiao L, et al. ?-NETA induces pyroptosis of epithelial ovarian cancer cells through the GSDMD/caspase-4 pathway. FASEB J. 2019 Nov;33(11):12760-12767.