TargetMol

Tapotoclax

Product Code:
 
TAR-T14213
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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This product comes from: United States.
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Further Information

Bioactivity:
AMG-176 is a MCL-1 inhibitor (Ki: 0.13 nM).
CAS:
1883727-34-1
Formula:
C33H41ClN2O5S
Molecular Weight:
613.21
Pathway:
Apoptosis
Purity:
0.98
SMILES:
[H][C@@]12CC[C@@]1([H])[C@@H](OC)C=CC[C@H](C)[C@@H](C)S(=O)(=O)NC(=O)c1ccc3OC[C@]4(CCCc5cc(Cl)ccc45)CN(C2)c3c1
Target:
BCL

References

1. Caenepeel S, et al. AMG 176, a Selective MCL1 Inhibitor, is Effective in Hematological Cancer Models Alone and in Combination with Established Therapies. Cancer Discov. 2018 Sep 25. pii: CD-18-0387. 2. Garner TP, et al. Progress in targeting the BCL-2 family of proteins. Curr Opin Chem Biol. 2017 Aug;39:133-142.