TargetMol

ARP-100

Product Code:
 
TAR-T14322
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T14322-5mg5mg£122.00
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TAR-T14322-1mL1 mL * 10 mM (in DMSO)£127.00
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TAR-T14322-10mg10mg£149.00
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TAR-T14322-25mg25mg£230.00
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TAR-T14322-50mg50mg£369.00
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TAR-T14322-100mg100mg£550.00
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This product comes from: United States.
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Further Information

Bioactivity:
ARP-100 is a potent and selective matrix metalloproteinase MMP-2 inhibitor (IC50=12 nM). ARP-100 interacts with the S1' pocket of MMP-2 and exhibits anti-invasive properties in an in vitro invasion Matrigel model. ARP-100 has low inhibitory activity against MMP-1 (>50 μM), MMP-3 (4.5 μM), MMP-7 (>50 μM) and MMP-9 (0.2 μM)[1][2].
CAS:
704888-90-4
Formula:
C17H20N2O5S
Molecular Weight:
364.42
Pathway:
Proteases/Proteasome
Purity:
0.9834
SMILES:
CC(C)ON(CC(=O)NO)S(=O)(=O)c1ccc(cc1)-c1ccccc1
Target:
MMP

References

1. Rossello A, et al. New N-arylsulfonyl-N-alkoxyaminoacetohydroxamic acids as selective inhibitors of gelatinase A (MMP-2). Bioorg Med Chem. 2004 May 1;12(9):2441-50. 2. Tuccinardi T, et al. Amber force field implementation, molecular modelling study, synthesis and MMP-1/MMP-2 inhibition profile of (R)- and (S)-N-hydroxy-2-(N-isopropoxybiphenyl-4-ylsulfonamido)-3-methylbutanamides. Bioorg Med Chem. 2006 Jun 15;14(12):4260-76.