TargetMol

Auristatin E

Product Code:
 
TAR-T14348
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T14348-5mg5mg£109.00
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TAR-T14348-10mg10mg£130.00
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TAR-T14348-1mL1 mL * 10 mM (in DMSO)£145.00
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TAR-T14348-25mg25mg£178.00
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TAR-T14348-50mg50mg£250.00
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This product comes from: United States.
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Further Information

Bioactivity:
Auristatin E inhibits cell division by blocking the polymerisation of tubulin. Auristatin E is a cytotoxic tubulin modifier with potent and selective antitumor activity. Auristatin E, an MMAE analog, is cytotoxin in Antibody-drug conjugates.
CAS:
160800-57-7
Formula:
C40H69N5O7
Molecular Weight:
732.02
Pathway:
Cytoskeletal Signaling
Purity:
0.9881
SMILES:
[H][C@]1(CCCN1C(=O)C[C@@H](OC)[C@H]([C@@H](C)CC)N(C)C(=O)[C@@H](NC(=O)[C@H](C(C)C)N(C)C)C(C)C)[C@H](OC)[C@@H](C)C(=O)N[C@H](C)[C@@H](O)c1ccccc1
Target:
Microtubule Associated

References

1. Francisco JA, et al. cAC10-vcMMAE, an anti-CD30-monomethyl auristatin E conjugate with potent and selective antitumor activity. Blood. 2003 Aug 15;102(4):1458-65. 2. Li D, et al. DCDT2980S, an anti-CD22-monomethyl auristatin E antibody-drug conjugate, is a potential treatment for non-Hodgkin lymphoma. Mol Cancer Ther. 2013 Jul;12(7):1255-65.