TargetMol

BAY-707

Product Code:
 
TAR-T14509
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T14509-5mg5mg£850.00
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TAR-T14509-50mg50mg£1,661.00
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TAR-T14509-100mg100mg£2,079.00
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Further Information

Bioactivity:
BAY-707 is well-tolerated in mice, but shows a clear lack of in vitro or in vivo anticancer efficacy[1] and it is a substrate-competitive, highly potent and selective inhibitor of MTH1(NUDT1) with an IC50 of 2.3 nM. BAY-707 has a good pharmacokinetic (PK) profile to other MTH1 compounds
CAS:
2109805-96-9
Formula:
C15H20N4O2
Molecular Weight:
288.351
Purity:
0.98
SMILES:
CCNC(=O)c1cc2c(ccnc2[nH]1)N1CCOC[C@@H]1C

References

1. Ellermann M, et al. Novel Class of Potent and Cellularly Active Inhibitors Devalidates MTH1 as Broad-Spectrum Cancer Target.ACS Chem Biol. 2017 Aug 18;12(8):1986-1992.