TargetMol

GNE-955

Product Code:
 
TAR-T15406
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T15406-5mg5mg£1,091.00
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TAR-T15406-50mg50mg£2,143.00
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Quantity:
TAR-T15406-100mg100mg£2,801.00
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This product comes from: United States.
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Further Information

Bioactivity:
GNE-955 is a potent and orally active inhibitor of pan Pim kinase (Kis: 0.018, 0.11, 0.08 nM for Pim1, Pim2, Pim3, respectively).
CAS:
1527523-39-2
Formula:
C22H24N8O
Molecular Weight:
416.489
Pathway:
JAK/STAT signaling; Chromatin/Epigenetic
Purity:
0.98
SMILES:
COc1ccc(nc1N1CCC[C@H](N)C1)-n1ncc2cnc(cc12)-c1cncc(C)n1
Target:
Pim

References

1. Wang X, et al. Discovery of 5-Azaindazole (GNE-955) as a Potent Pan-Pim Inhibitor with Optimized Bioavailability. J Med Chem. 2017 May 25;60(10):4458-4473.