TargetMol

ICA-27243

Product Code:
 
TAR-T15545
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T15545-1mg1mg£95.00
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TAR-T15545-5mg5mg£128.00
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TAR-T15545-1mL1 mL * 10 mM (in DMSO)£134.00
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TAR-T15545-10mg10mg£168.00
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TAR-T15545-25mg25mg£257.00
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TAR-T15545-50mg50mg£402.00
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TAR-T15545-100mg100mg£567.00
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Further Information

Bioactivity:
ICA-27243 is less effective at activating KCNQ4 and KCNQ3/Q5. ICA-27243 is a potent and orally active KCNQ2/Q3 potassium channel opener (EC50: 0.38 μM). ICA-27243 also has antiepileptic and anticonvulsant effects.
CAS:
325457-89-4
Formula:
C12H7ClF2N2O
Molecular Weight:
268.65
Pathway:
Membrane transporter/Ion channel
Purity:
0.9979
SMILES:
Fc1ccc(cc1F)C(=O)Nc1ccc(Cl)nc1
Target:
Potassium Channel

References

1. Wickenden AD, et al. N-(6-chloro-pyridin-3-yl)-3,4-difluoro-benzamide (ICA-27243): a novel, selective KCNQ2/Q3 potassium channel activator. Mol Pharmacol. 2008 Mar;73(3):977-86. 2. Amato G, et al. N-Pyridyl and Pyrimidine Benzamides as KCNQ2/Q3 Potassium Channel Openers for the Treatment of Epilepsy. ACS Med Chem Lett. 2011 Mar 31;2(6):481-4.