TargetMol

PF-03715455

Product Code:
 
TAR-T16477
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T16477-5mg5mg£1,492.00
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TAR-T16477-50mg50mg£2,946.00
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Quantity:
TAR-T16477-100mg100mg£4,006.00
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This product comes from: United States.
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Further Information

Bioactivity:
PF-03715455 potently inhibits LPS-induced TNFα production in human whole blood (IC50=1.7 nM). PF-03715455 is an effective inhibitor of inhaled p38 MAPK. PF-03715455 displays some selectivity for p38α over p38β (respective IC50: 0.88 and 23 nM). PF-03715455 has the potential for the treatment of COPD.
CAS:
1056164-52-3
Formula:
C35H34ClN7O3S2
Molecular Weight:
700.27
Pathway:
MAPK
Purity:
0.98
SMILES:
CC(C)(C)c1cc(NC(=O)NCc2ccccc2Sc2ccc3nnc(-c4ccccc4SCCO)n3c2)n(n1)-c1ccc(O)c(Cl)c1
Target:
p38 MAPK

References

1. Norman P, et al. Investigational p38 inhibitors for the treatment of chronic obstructive pulmonary disease. Expert Opin Investig Drugs. 2015 Mar;24(3):383-92. 2. Millan DS, et al. Design and synthesis of inhaled p38 inhibitors for the treatment of chronic obstructive pulmonary disease. J Med Chem. 2011 Nov 24;54(22):7797-814.