TargetMol

P7C3

Product Code:
 
TAR-T1880
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T1880-5mg5mg£105.00
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TAR-T1880-1mL1 mL * 10 mM (in DMSO)£109.00
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TAR-T1880-10mg10mg£127.00
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TAR-T1880-25mg25mg£177.00
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TAR-T1880-50mg50mg£262.00
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TAR-T1880-100mg100mg£389.00
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Further Information

Bioactivity:
The P7C3 class of neuroprotective aminopropyl carbazoles has been shown to block neuronal cell death in models of neurodegeneration. We now show that P7C3 molecules additionally preserve axonal integrity after injury, before neuronal cell death occurs, in a rodent model of blast-mediated traumatic brain injury (TBI). This protective quality may be linked to the ability of P7C3 molecules to activate nicotinamide phosphoribosyltransferase, the rate-limiting enzyme in nicotinamide adenine dinucleotide salvage.
CAS:
301353-96-8
Formula:
C21H18Br2N2O
Molecular Weight:
474.196
Purity:
0.996
SMILES:
OC(CNc1ccccc1)Cn1c2ccc(Br)cc2c2cc(Br)ccc12

References

1. Wang G, et al. Cell. 2014, 158(6), 1324-1334. 2. Pieper AA, et al. Cell. 2010, 142(1), 39-51. 3. Latchney SE, et al. Neurosci Lett. 2015, 591, 86-92.