TargetMol

Kazinol B

Product Code:
 
TAR-T20232
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T20232-5mg5mg£1,484.00
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Further Information

Bioactivity:
Kazinol B is a natural isoprenylated flavan. It also stimulates the gene expression and secretion of adiponectin.
CAS:
99624-27-8
Formula:
C30H36O4
Molecular Weight:
460.614
Pathway:
Chromatin/Epigenetic|Immunology/Inflammation|PI3K/Akt/mTOR signaling|Cytoskeletal Signaling
Purity:
0.98
SMILES:
CC(C)=CCc1c(O)c(O)cc(C2=CC=C3CC(=C(O)C=C3O2)C(C)(C)C=C)c1CC=C(C)C
Target:
NO Synthase|Akt|AMPK

References

1. Lee H, Li H, Jeong JH, Noh M, Ryu JH. Kazinol B from Broussonetia kazinoki improves insulin sensitivity via Akt and AMPK activation in 3T3-L1 adipocytes. Fitoterapia. 2016 Jul;112:90-6. doi: 10.1016/j.fitote.2016.05.006. Epub 2016 May 17. PubMed PMID: 27223849. 2. Ryu JH, Ahn H, Jin Lee H. Inhibition of nitric oxide production on LPS-activated macrophages by kazinol B from Broussonetia kazinoki. Fitoterapia. 2003 Jun;74(4):350-4. PubMed PMID: 12781805. 3. Wang JP, Tsao LT, Raung SL, Lin CN. The signal transduction mechanism involved in kazinol B-stimulated superoxide anion generation in rat neutrophils. Br J Pharmacol. 1998 Oct;125(3):517-25. PubMed PMID: 9806335; PubMed Central PMCID: PMC1565651. 4. Wang JP, Hsu MF, Ko HH, Lin CN. Stimulation of cellular free Ca2+ elevation and inhibition of store-operated Ca2+ entry by kazinol B in neutrophils. Naunyn Schmiedebergs Arch Pharmacol. 2004 Dec;370(6):500-9. Epub 2004 Nov 19. PubMed PMID: 15558242.