TargetMol

3PO

Product Code:
 
TAR-T22223
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T22223-5mg5mg£112.00
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TAR-T22223-1mL1 mL * 10 mM (in DMSO)£117.00
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TAR-T22223-10mg10mg£130.00
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TAR-T22223-25mg25mg£174.00
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TAR-T22223-50mg50mg£230.00
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TAR-T22223-100mg100mg£358.00
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TAR-T22223-200mg200mg£499.00
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TAR-T22223-500mg500mg£752.00
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Further Information

Bioactivity:
3PO is a small-molecule inhibitor of PFKFB3 (IC50: 22.9 μM), inhibiting the proliferation of several human malignant hematopoietic and adenocarcinoma cell lines (IC50: 1.4-24 μM). It suppresses glucose uptake, and decreases the intracellular concentration of Fru-2,6-BP, lactate, ATP, NAD+, and NADH.
CAS:
18550-98-6
Formula:
C13H10N2O
Molecular Weight:
210.23
Pathway:
Autophagy; Metabolism
Purity:
0.9967
SMILES:
O=C(/C=C/c1cnccc1)c1ccncc1
Target:
Glucokinase; Autophagy

References

1. Clem B, et al. Small-molecule inhibition of 6-phosphofructo-2-kinase activity suppresses glycolytic flux and tumor growth. Mol Cancer Ther. 2008 Jan;7(1):110-20. 2. Schoors S, et al. Partial and transient reduction of glycolysis by PFKFB3 blockade reduces pathological angiogenesis. Cell Metab. 2014 Jan 7;19(1):37-48. 3. Lea MA, Inhibition of Growth of Bladder Cancer Cells by 3-(3-Pyridinyl)-1-(4-pyridinyl)-2-propen-1-one in Combination with Other Compounds Affecting Glucose Metabolism. Anticancer Res. 2015 Nov;35(11):5889-99.