TargetMol

m-Chlorophenylbiguanide hydrochloride

Product Code:
 
TAR-T22959
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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TAR-T22959-100mg100mg£104.00
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Further Information

Bioactivity:
m-Chlorophenylbiguanide hydrochloride is a 5-HT3 receptor agonist. m-Chlorophenylbiguanide hydrochloride selectively binds 5-HT3(Ki: 0.002 ?M) over 5-HT1A(Ki: 10 ?M) and 5-HT2(Ki: 10 ?M) receptors but also binds to high and low affinity sites on the dopamine transporter(DAT; IC50s: 0.4 and 34.8 ?M, respectively, in rat caudate putamen synaptosomal membranes).
CAS:
2113-05-5
Formula:
C8H11Cl2N5
Molecular Weight:
248.11
Pathway:
GPCR/G Protein; Neuroscience
Purity:
0.9987
SMILES:
Cl.NC(=N)NC(=N)Nc1cccc(Cl)c1
Target:
5-HT Receptor

References

1. Kilpatrick GJ, et al. 1-(m-chlorophenyl)-biguanide, a potent high affinity 5-HT3 receptor agonist. Eur J Pharmacol. 1990 Jun 21;182(1):193-7. 2. Campbell AD, Womer DE, Simon JR. The 5-HT3 receptor agonist 1-(m-chlorophenyl)-biguanide interacts with the dopamine transporter in rat brain synaptosomes. Eur J Pharmacol. 1995 Jul 18;290(2):157-62. 3. Higgins GA, Joharchi N, Sellers EM. Behavioral effects of the 5-hydroxytryptamine3 receptor agonists 1-phenylbiguanide and m-chlorophenylbiguanide in rats. J Pharmacol Exp Ther. 1993 Mar;264(3):1440-9. 4. Edwards E, et al. 5-HT3-like receptors in the rat medial prefrontal cortex: further pharmacological characterization. Brain Res. 1996 Sep 9;733(1):21-30.