TargetMol

TC-N 1752

Product Code:
 
TAR-T23439
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T23439-1mg1mg£111.00
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TAR-T23439-5mg5mg£168.00
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TAR-T23439-1mL1 mL * 10 mM (in DMSO)£177.00
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TAR-T23439-10mg10mg£230.00
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TAR-T23439-25mg25mg£436.00
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TAR-T23439-50mg50mg£610.00
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TAR-T23439-100mg100mg£838.00
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This product comes from: United States.
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Further Information

Bioactivity:
TC-N 1752 is an orally active inhibitor of Nav1.7 channel with IC50 of 0.17 μM. TC-N 1752 shows analgesic activities.
CAS:
1211866-85-1
Formula:
C25H27F3N6O3
Molecular Weight:
516.52
Pathway:
Membrane transporter/Ion channel
Purity:
0.9787
SMILES:
O=C(NC=1C=CC=C(NC2=NC=NC(=N2)N3CCC(OCC4=CC=C(OC(F)(F)F)C=C4)CC3)C1C)C
Target:
Sodium Channel

References

1. Lin Z, et, al. Biophysical and Pharmacological Characterization of Nav1.9 Voltage Dependent Sodium Channels Stably Expressed in HEK-293 Cells. PLoS One. 2016 Aug 24;11(8):e0161450. 2. Matson DJ, et, al. Inhibition of Inactive States of Tetrodotoxin-Sensitive Sodium Channels Reduces Spontaneous Firing of C-Fiber Nociceptors and Produces Analgesia in Formalin and Complete Freund's Adjuvant Models of Pain. PLoS One. 2015 Sep 17;10(9):e013 3. Bregman H, et, al. Identification of a potent, state-dependent inhibitor of Nav1.7 with oral efficacy in the formalin model of persistent pain. J Med Chem. 2011 Jul 14;54(13):4427-45.