TargetMol

Akt Inhibitor X

Product Code:
 
TAR-T23694
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T23694-5mg5mg£850.00
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.
Quantity:
TAR-T23694-50mg50mg£1,661.00
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.
Quantity:
TAR-T23694-100mg100mg£2,079.00
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.
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This product comes from: United States.
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Further Information

Bioactivity:
Akt Inhibitor X is a cell-permeable and reversible inhibitor of Akt phosphorylation.
CAS:
201788-90-1
Formula:
C20H26Cl2N2O
Molecular Weight:
381.34
Purity:
0.98
SMILES:
CCN(CCCCN1C2=CC(Cl)=CC=C2OC3=C1C=CC=C3)CC.Cl

References

1. Varela-M RE, Ochoa R, Muskus CE, Muro A, Mollinedo F. Identification of a RAC/AKT-like gene in Leishmania parasites as a putative therapeutic target in leishmaniasis. Parasit Vectors. 2017 Oct 10;10(1):458. doi: 10.1186/s13071-017-2379-y. PubMed PMID: 29017516; PubMed Central PMCID: PMC5633885. 2. Zhang R, Zhu Y, Dong X, Liu B, Zhang N, Wang X, Liu L, Xu C, Huang S, Chen L. Celastrol Attenuates Cadmium-Induced Neuronal Apoptosis via Inhibiting Ca(2+) -CaMKII-Dependent Akt/mTOR Pathway. J Cell Physiol. 2017 Aug;232(8):2145-2157. doi: 10.1002/jcp.25703. Epub 2017 Feb 28. PubMed PMID: 27891586. 3. Xu C, Zhang H, Liu C, Zhu Y, Wang X, Gao W, Huang S, Chen L. Rapamycin inhibits Erk1/2-mediated neuronal apoptosis caused by cadmium. Oncotarget. 2015 Aug 28;6(25):21452-67. PubMed PMID: 26046303; PubMed Central PMCID: PMC4673278. 4. de Oliveira AC, Candelario-Jalil E, Langbein J, Wendeburg L, Bhatia HS, Schlachetzki JC, Biber K, Fiebich BL. Pharmacological inhibition of Akt and downstream pathways modulates the expression of COX-2 and mPGES-1 in activated microglia. J Neuroinflammation. 2012 Jan 3;9:2. doi: 10.1186/1742-2094-9-2. PubMed PMID: 22214188; PubMed Central PMCID: PMC3283507.