TargetMol

AMG8163

Product Code:
 
TAR-T23723
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T23723-5mg5mg£930.00
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Quantity:
TAR-T23723-50mg50mg£1,821.00
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Quantity:
TAR-T23723-100mg100mg£2,319.00
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This product comes from: United States.
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  • Further Information
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Further Information

Bioactivity:
AMG8163 is an antagonist of vanilloid receptor TRPV1.
CAS:
659731-59-6
Formula:
C25H22F3N5O4S
Molecular Weight:
545.54
Purity:
0.98
SMILES:
CC(=O)Nc1nc2c(Oc3cc(ncn3)-c3ccc(cc3NC(=O)OC(C)(C)C)C(F)(F)F)cccc2s1

References

1. Gavva NR, Bannon AW, Hovland DN Jr, Lehto SG, Klionsky L, Surapaneni S, Immke DC, Henley C, Arik L, Bak A, Davis J, Ernst N, Hever G, Kuang R, Shi L, Tamir R, Wang J, Wang W, Zajic G, Zhu D, Norman MH, Louis JC, Magal E, Treanor JJ. Repeated administration of vanilloid receptor TRPV1 antagonists attenuates hyperthermia elicited by TRPV1 blockade. J Pharmacol Exp Ther. 2007 Oct;323(1):128-37. Epub 2007 Jul 25. PubMed PMID: 17652633. 2. Gavva NR, Bannon AW, Surapaneni S, Hovland DN Jr, Lehto SG, Gore A, Juan T, Deng H, Han B, Klionsky L, Kuang R, Le A, Tamir R, Wang J, Youngblood B, Zhu D, Norman MH, Magal E, Treanor JJ, Louis JC. The vanilloid receptor TRPV1 is tonically activated in vivo and involved in body temperature regulation. J Neurosci. 2007 Mar 28;27(13):3366-74. PubMed PMID: 17392452.