TargetMol

BMS-986169

Product Code:
 
TAR-T23808
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T23808-5mg5mg£1,171.00
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TAR-T23808-50mg50mg£2,303.00
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TAR-T23808-100mg100mg£3,042.00
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Further Information

Bioactivity:
BMS-986169 is a GluN2B Receptor Negative Allosteric Modulator. BMS-986169 showed a high binding affinity for the GluN2B subunit allosteric modulatory site (Ki: 4.03-6.3 nM) and selectively inhibited GluN2B receptor function in Xenopus oocytes expressing human N-methyl-d-aspartate receptor subtypes (IC50: 24.1 nM).
CAS:
1801151-08-5
Formula:
C23H27FN2O2
Molecular Weight:
382.479
Purity:
0.98
SMILES:
Cc1ccc(CN2CC[C@@H](N3CC[C@H]([C@H](F)C3)c3ccc(O)cc3)C2=O)cc1

References

1. Bristow LJ, Gulia J, Weed MR,et al. Preclinical Characterization of (R)-3-((3S,4S)-3-fluoro-4-(4-hydroxyphenyl)piperidin-1-yl)-1-(4-methylbenzyl)pyrr olidin-2-one (BMS-986169), a Novel, Intravenous, Glutamate N-Methyl-d-Aspartate
2B Receptor Negative Allosteric Modulator with Potential in Major Depressive Disorder. J Pharmacol Exp Ther. 2017 Dec;363(3):377-393. doi: 10.1124/jpet.117.242784. Epub 2017 Sep 27. PubMed PMID: 28954811. 2. BMS-986163, a Negative Allosteric Modulator of GluN2B with Potential Utility in Major Depressive Disorder Lawrence R. Marcin, Jayakumar Warrier, Srinivasan Thangathirupathy, and John E. Macor Publication Date (Web): April 13, 2018 (Letter) doi: 10.1021/acsmedchemlett.8b00080