TargetMol

Bozepinib

Product Code:
 
TAR-T23813
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T23813-5mg5mg£850.00
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TAR-T23813-50mg50mg£1,661.00
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TAR-T23813-100mg100mg£2,079.00
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Further Information

Bioactivity:
Bozepinib is an antitumor compound that acts by inducing PKR-mediated apoptosis and synergizing with IFN.
CAS:
1207993-83-6
Formula:
C20H14Cl2N6O5S
Molecular Weight:
521.33
Purity:
0.98
SMILES:
[O-][N+](=O)c1ccc(cc1)S(=O)(=O)N1CC(OCc2ccccc12)n1cnc2c(Cl)nc(Cl)nc12

References

1. Cruz-L?pez O, Ram?rez A, Navarro SA, Garc?a MA, Marchal JA, Campos JM, Conejo-Garc?a A. 1-(Benzenesulfonyl)-1,5-dihydro-4,1-benzoxazepine as a new scaffold for the design of antitumor compounds. Future Med Chem. 2017 Jul;9(11):1129-1140. doi: 10.4155/fmc-2017-0006. Epub 2017 Jul 19. PubMed PMID: 28722472. 2. Ram?rez A, Boulaiz H, Morata-Tarifa C, Per?n M, Jim?nez G, Picon-Ruiz M, Agil A, Cruz-L?pez O, Conejo-Garc?a A, Campos JM, S?nchez A, Garc?a MA, Marchal JA. HER2-signaling pathway, JNK and ERKs kinases, and cancer stem-like cells are targets of Bozepinib small compound. Oncotarget. 2014 Jun 15;5(11):3590-606. PubMed PMID: 24946763; PubMed Central PMCID: PMC4116505. 3. Marchal JA, Carrasco E, Ramirez A, Jim?nez G, Olmedo C, Peran M, Agil A, Conejo-Garc?a A, Cruz-L?pez O, Campos JM, Garc?a M?. Bozepinib, a novel small antitumor agent, induces PKR-mediated apoptosis and synergizes with IFN? triggering apoptosis, autophagy and senescence. Drug Des Devel Ther. 2013 Oct 29;7:1301-13. doi: 10.2147/DDDT.S51354. eCollection 2013. PubMed PMID: 24194639; PubMed Central PMCID: PMC3815003. 4. L?pez-Cara LC, Conejo-Garc?a A, Marchal JA, Macchione G, Cruz-L?pez O, Boulaiz H, Garc?a MA, Rodr?guez-Serrano F, Ram?rez A, Cativiela C, Jim?nez AI, Garc?a-Ruiz JM, Choquesillo-Lazarte D, Ar?nega A, Campos JM. New (RS)-benzoxazepin-purines with antitumour activity: The chiral switch from (RS)-2,6-dichloro-9-[1-(p-nitrobenzenesulfonyl)-1,2,3,5-tetrahydro-4,1-benzoxazep in-3-yl]-9H-purine. Eur J Med Chem. 2011 Jan;46(1):249-58. doi: 10.1016/j.ejmech.2010.11.011. Epub 2010 Dec 3. PubMed PMID: 21126804.