TargetMol

GCA-186

Product Code:
 
TAR-T24087
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T24087-5mg5mg£930.00
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TAR-T24087-50mg50mg£1,821.00
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Quantity:
TAR-T24087-100mg100mg£2,319.00
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This product comes from: United States.
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  • Further Information
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Further Information

Bioactivity:
GCA-186 is an effective non-nucleoside HIV-1 reverse transcriptase inhibitor.
CAS:
149950-61-8
Formula:
C19H26N2O3
Molecular Weight:
330.428
Purity:
0.98
SMILES:
CCOCn1c(Cc2cc(C)cc(C)c2)c(C(C)C)c(=O)[nH]c1=O

References

1. El-Brollosy NR, S?rensen ER, Pedersen EB, Sanna G, La Colla P, Loddo R. Synthesis and antiviral evaluation of 6-(trifluoromethylbenzyl) and 6-(fluorobenzyl) analogues of HIV drugs emivirine and GCA-186. Arch Pharm (Weinheim). 2008 Jan;341(1):9-19. PubMed PMID: 18161905. 2. S?rensen ER, El-Brollosy NR, J?rgensen PT, Pedersen EB, Nielsen C. Synthesis of 6-(3,5-dichlorobenzyl) derivatives as isosteric analogues of the HIV drug 6-(3,5-dimethylbenzyl)-1-(ethoxymethyl)-5-isopropyluracil (GCA-186). Arch Pharm (Weinheim). 2005 Jul;338(7):299-304. PubMed PMID: 15996003. 3. Hopkins AL, Ren J, Tanaka H, Baba M, Okamato M, Stuart DI, Stammers DK. Design of MKC-442 (emivirine) analogues with improved activity against drug-resistant HIV mutants. J Med Chem. 1999 Nov 4;42(22):4500-5. PubMed PMID: 10579814.