TargetMol

L 680833

Product Code:
 
TAR-T24328
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T24328-5mg5mg£1,010.00
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TAR-T24328-50mg50mg£1,982.00
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Quantity:
TAR-T24328-100mg100mg£2,560.00
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This product comes from: United States.
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Further Information

Bioactivity:
L 680833 is an orally active monocyclic beta-lactam human polymorphonuclear leukocyte elastase inhibitor.
CAS:
127063-08-5
Formula:
C27H34N2O5
Molecular Weight:
466.578
Purity:
0.98
SMILES:
CCC[C@@H](NC(=O)N1[C@@H](Oc2ccc(CC(O)=O)cc2)C(CC)(CC)C1=O)c1ccc(C)cc1

References

1. Dwyer TM, Farley JM. Human neutrophil elastase releases two pools of mucinlike glycoconjugate from tracheal submucosal gland cells. Am J Physiol Lung Cell Mol Physiol. 2000 Apr;278(4):L675-82. PubMed PMID: 10749744. 2. Macchia B, Gentili D, Macchia M, Mamone F, Martinelli A, Orlandini E, Rossello A, Cercignani G, Pierotti R, Allegretti M, Asti C, Caselli G. Synthesis, inhibitory activity towards human leukocyte elastase and molecular modelling studies of 1-carbamoyl-4-methyleneaminoxyazetidinones. Eur J Med Chem. 2000 Jan;35(1):53-67. PubMed PMID: 10733603. 3. Sk?ld CM, Liu X, Umino T, Zhu Y, Ohkuni Y, Romberger DJ, Spurzem JR, Heires AJ, Rennard SI. Human neutrophil elastase augments fibroblast-mediated contraction of released collagen gels. Am J Respir Crit Care Med. 1999 Apr;159(4 Pt 1):1138-46. PubMed PMID: 10194158. 4. Rees DD, Brain JD. Effects of cystic fibrosis airway secretions on rat lung: role of neutrophil elastase. Am J Physiol. 1995 Aug;269(2 Pt 1):L195-202. PubMed PMID: 7653580.