TargetMol

PF04677490

Product Code:
 
TAR-T24615
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T24615-5mg5mg£850.00
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.
Quantity:
TAR-T24615-50mg50mg£1,661.00
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.
Quantity:
TAR-T24615-100mg100mg£2,079.00
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.
Quantity:
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This product comes from: United States.
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Further Information

Bioactivity:
PF04677490 is an effective PDE1 inhibitor. PF04677490 efficaciously inhibits cAMP- and cGMP-hydrolytic activity in preparations from human myocardium at concentrations selective for PDE1.
CAS:
1628342-10-8
Formula:
C17H21N5O2
Molecular Weight:
327.388
Purity:
0.98
SMILES:
COc1ccc2c(NC(C)Cc3cc(C)[nH]n3)ncnc2c1OC

References

1. Discovery of Potent and Selective Periphery-Restricted Quinazoline Inhibitors of the Cyclic Nucleotide Phosphodiesterase PDE1 John M. Humphrey, Matthew Movsesian, Christopher W. am Ende, Stacey L. Becker, Thomas A. Chappie, Stephen Jenkinson, Jennifer L. Liras, Spiros Liras, Christine Orozco, Jayvardhan Pandit, Felix F. Vajdos, Fabrice Vandeput, Eddie Yang, and Frank S. Menniti Publication Date (Web): May 2, 2018 (Brief Article) doi: 10.1021/acs.jmedchem.8b00374