TargetMol

PK-THPP

Product Code:
 
TAR-T24648
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T24648-5mg5mg£930.00
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.
Quantity:
TAR-T24648-50mg50mg£1,821.00
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.
Quantity:
TAR-T24648-100mg100mg£2,319.00
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.
Quantity:
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This product comes from: United States.
Typical lead time: 10-14 working days.
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Further Information

Bioactivity:
PK-THPP is a channel blocker of TASK-3.
CAS:
1332454-07-5
Formula:
C29H32N4O2
Molecular Weight:
468.601
Purity:
0.98
SMILES:
CCCC(=O)C1CCN(CC1)c1ncnc2CCN(Cc12)C(=O)c1ccc(cc1)-c1ccccc1

References

1. Srisomboon Y, Zaidman NA, Maniak PJ, Deachapunya C, O'Grady SM. P2Y receptor regulation of K2P channels that facilitate K(+) secretion by human mammary epithelial cells. Am J Physiol Cell Physiol. 2018 Jan 24. doi: 10.1152/ajpcell.00342.2016. [Epub ahead of print] PubMed PMID: 29365273. 2. Feng HJ, Faingold CL. Abnormalities of serotonergic neurotransmission in animal models of SUDEP. Epilepsy Behav. 2017 Jun;71(Pt B):174-180. doi: 10.1016/j.yebeh.2015.06.008. Epub 2015 Aug 10. Review. PubMed PMID: 26272185; PubMed Central PMCID: PMC4749463. 3. Zeng C, Long X, Cotten JF, Forman SA, Solt K, Faingold CL, Feng HJ. Fluoxetine prevents respiratory arrest without enhancing ventilation in DBA/1 mice. Epilepsy Behav. 2015 Apr;45:1-7. doi: 10.1016/j.yebeh.2015.02.013. Epub 2015 Mar 13. PubMed PMID: 25771493; PubMed Central PMCID: PMC4424071. 4. Cotten JF. TASK-1 (KCNK3) and TASK-3 (KCNK9) tandem pore potassium channel antagonists stimulate breathing in isoflurane-anesthetized rats. Anesth Analg. 2013 Apr;116(4):810-6. doi: 10.1213/ANE.0b013e318284469d. Epub 2013 Mar 4. PubMed PMID: 23460565; PubMed Central PMCID: PMC3865919.