TargetMol

RUC-1

Product Code:
 
TAR-T24745
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T24745-5mg5mg£850.00
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Quantity:
TAR-T24745-50mg50mg£1,661.00
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Quantity:
TAR-T24745-100mg100mg£2,079.00
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This product comes from: United States.
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  • Further Information
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Further Information

Bioactivity:
RUC-1 is an αIIbβ3-selective ADP-induced platelet aggregation inhibitor.
CAS:
796886-30-1
Formula:
C11H15N5OS
Molecular Weight:
265.34
Purity:
0.98
SMILES:
CCc1nn2c(nc(cc2=O)N2CCNCC2)s1

References

1. Negri A, Li J, Naini S, Coller BS, Filizola M. Structure-based virtual screening of small-molecule antagonists of platelet integrin ?IIb?3 that do not prime the receptor to bind ligand. J Comput Aided Mol Des. 2012 Sep;26(9):1005-15. doi: 10.1007/s10822-012-9594-6. Epub 2012 Aug 15. PubMed PMID: 22893377; PubMed Central PMCID: PMC3496400. 2. Zhu J, Choi WS, McCoy JG, Negri A, Zhu J, Naini S, Li J, Shen M, Huang W, Bougie D, Rasmussen M, Aster R, Thomas CJ, Filizola M, Springer TA, Coller BS. Structure-guided design of a high-affinity platelet integrin ?IIb?3 receptor antagonist that disrupts Mg?? binding to the MIDAS. Sci Transl Med. 2012 Mar 14;4(125):125ra32. doi: 10.1126/scitranslmed.3003576. PubMed PMID: 22422993; PubMed Central PMCID: PMC3390238. 3. Zhu J, Zhu J, Negri A, Provasi D, Filizola M, Coller BS, Springer TA. Closed headpiece of integrin ?IIb?3 and its complex with an ?IIb?3-specific antagonist that does not induce opening. Blood. 2010 Dec 2;116(23):5050-9. doi: 10.1182/blood-2010-04-281154. Epub 2010 Aug 2. PubMed PMID: 20679525; PubMed Central PMCID: PMC3012599. 4. Blue R, Kowalska MA, Hirsch J, Murcia M, Janczak CA, Harrington A, Jirouskova M, Li J, Fuentes R, Thornton MA, Filizola M, Poncz M, Coller BS. Structural and therapeutic insights from the species specificity and in vivo antithrombotic activity of a novel alphaIIb-specific alphaIIbbeta3 antagonist. Blood. 2009 Jul 2;114(1):195-201. doi: 10.1182/blood-2008-08-169243. Epub 2009 May 4. PubMed PMID: 19414864; PubMed Central PMCID: PMC2710948.