TargetMol

Aklanonic acid

Product Code:
 
TAR-T25013
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
❮❯

No additional charges, what you see is what you pay! *

CodeSizePrice
TAR-T25013-5mg5mg£850.00
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.
Quantity:
Prices exclude any Taxes / VAT
How to order with us   Contact us
Stay in control of your spending. These prices have no additional charges, not even shipping!
* Rare exceptions are clearly labelled (only 0.14% of items!).
Multibuy discounts available! Contact us to find what you can save.
This product comes from: United States.
Typical lead time: 10-14 working days.
Contact us for more accurate information.
  • Further Information
  • Documents
  • References
  • Show All

Further Information

Bioactivity:
Aklanonic acid is an intermediate in the biosynthesis of anthracycline antibiotics from Streptomyces sp. ZIMET 43717.
CAS:
91432-47-2
Formula:
C21H16O8
Molecular Weight:
396.351
Purity:
0.98
SMILES:
CCC(=O)C=C(/O)c1c(CC(O)=O)cc2C(=O)c3cccc(O)c3C(=O)c2c1O

References

1. Castaldo G, Zucko J, Heidelberger S, Vujaklija D, Hranueli D, Cullum J, Wattana-Amorn P, Crump MP, Crosby J, Long PF. Proposed arrangement of proteins forming a bacterial type II polyketide synthase. Chem Biol. 2008 Nov 24;15(11):1156-65. doi: 10.1016/j.chembiol.2008.09.010. PubMed PMID: 19022176. 2. Kallio P, Sultana A, Niemi J, M?nts?l? P, Schneider G. Crystal structure of the polyketide cyclase AknH with bound substrate and product analogue: implications for catalytic mechanism and product stereoselectivity. J Mol Biol. 2006 Mar 17;357(1):210-20. Epub 2006 Jan 6. PubMed PMID: 16414075. 3. Lee TS, Khosla C, Tang Y. Engineered biosynthesis of aklanonic acid analogues. J Am Chem Soc. 2005 Sep 7;127(35):12254-62. PubMed PMID: 16131203; PubMed Central PMCID: PMC1343498. 4. Chung JY, Fujii I, Harada S, Sankawa U, Ebizuka Y. Expression, purification, and characterization of AknX anthrone oxygenase, which is involved in aklavinone biosynthesis in Streptomyces galilaeus. J Bacteriol. 2002 Nov;184(22):6115-22. PubMed PMID: 12399480; PubMed Central PMCID: PMC151955.