TargetMol

Akuammine

Product Code:
 
TAR-T25018
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T25018-5mg5mg£850.00
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Further Information

Bioactivity:
Akuammine is an antimalarial indolemonoterpene alkaloid from Picralima nitida seeds.
CAS:
3512-87-6
Formula:
C22H26N2O4
Molecular Weight:
382.46
Purity:
0.98
SMILES:
COC(=O)[C@]12CO[C@]34[C@@H]5C[C@H]1C(CN5CC[C@]23c1cc(O)ccc1N4C)=C/C

References

1. Moreno J, Picazo E, Morrill LA, Smith JM, Garg NK. Enantioselective Total Syntheses of Akuammiline Alkaloids (+)-Strictamine, (-)-2(S)-Cathafoline, and (-)-Aspidophylline A. J Am Chem Soc. 2016 Feb 3;138(4):1162-5. doi: 10.1021/jacs.5b12880. Epub 2016 Jan 19. PubMed PMID: 26783944; PubMed Central PMCID: PMC5154302. 2. Menzies JR, Paterson SJ, Duwiejua M, Corbett AD. Opioid activity of alkaloids extracted from Picralima nitida (fam. Apocynaceae). Eur J Pharmacol. 1998 May 29;350(1):101-8. PubMed PMID: 9683021. 3. Kapadia GJ, Angerhofer CK, Ansa-Asamoah R. Akuammine: an antimalarial indolemonoterpene alkaloid of Picralima nitida seeds. Planta Med. 1993 Dec;59(6):565-6. PubMed PMID: 8302957. 4. Lewin G, Le M?nez P, Rolland Y, Renouard A, Giesen-Crouse E. Akuammine and dihydroakuammine, two indolomonoterpene alkaloids displaying affinity for opioid receptors. J Nat Prod. 1992 Mar;55(3):380-4. PubMed PMID: 1317407.