TargetMol

Azalanstat

Product Code:
 
TAR-T25127
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T25127-5mg5mg£850.00
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TAR-T25127-50mg50mg£1,661.00
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Quantity:
TAR-T25127-100mg100mg£2,079.00
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This product comes from: United States.
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Further Information

Bioactivity:
Azalanstat is a lanosterol 14 alpha-demethylase inhibitor. The enzyme catalyzes the first step in the conversion of lanosterol to cholesterol in mammals.
CAS:
143393-27-5
Formula:
C22H24ClN3O2S
Molecular Weight:
429.96
Purity:
0.98
SMILES:
Nc1ccc(SC[C@@H]2CO[C@](CCc3ccc(Cl)cc3)(Cn3ccnc3)O2)cc1

References

1. Burton PM, Swinney DC, Heller R, Dunlap B, Chiou M, Malonzo E, Haller J, Walker KA, Salari A, Murakami S, et al. Azalanstat (RS-21607), a lanosterol 14 alpha-demethylase inhibitor with cholesterol-lowering activity. Biochem Pharmacol. 1995 Aug 8;50(4):529-44. PubMed PMID: 7646560. 2. Vlahakis JZ, Kinobe RT, Bowers RJ, Brien JF, Nakatsu K, Szarek WA. Synthesis and evaluation of azalanstat analogues as heme oxygenase inhibitors. Bioorg Med Chem Lett. 2005 Mar 1;15(5):1457-61. PubMed PMID: 15713406. 3. Morisawa T, Wong RJ, Bhutani VK, Vreman HJ, Stevenson DK. Inhibition of heme oxygenase activity in newborn mice by azalanstat. Can J Physiol Pharmacol. 2008 Oct;86(10):651-9. doi: 10.1139/y08-069. PubMed PMID: 18841169. 4. Pittal? V, Salerno L, Romeo G, Modica MN, Siracusa MA. A focus on heme oxygenase-1 (HO-1) inhibitors. Curr Med Chem. 2013;20(30):3711-32. Review. PubMed PMID: 23746277.