TargetMol

Leualacin

Product Code:
 
TAR-T25674
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T25674-5mg5mg£1,492.00
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TAR-T25674-50mg50mg£2,946.00
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Quantity:
TAR-T25674-100mg100mg£4,006.00
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  • Further Information
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Further Information

Bioactivity:
Leualacin is a novel calcium blocker from Hapsidospora irregularis.
CAS:
128140-12-5
Formula:
C31H47N3O7
Molecular Weight:
573.731
Purity:
0.98
SMILES:
CC(C)C[C@H](N)C(=O)[C@](C=O)(N(C)C(=O)[C@@H](O)CC(C)=C)[C@](C(=O)CCN)(C(=O)[C@H](O)CC(C)C)c1ccccc1

References

1. Hamano K, Kinoshita M, Furuya K, Miyamoto M, Takamatsu Y, Hemmi A, Tanzawa K. Leualacin, a novel calcium blocker from Hapsidospora irregularis. I. Taxonomy, fermentation, isolation, physico-chemical and biological properties. J Antibiot (Tokyo). 1992 Jun;45(6):899-905. Erratum in: J Antibiot (Tokyo) 1992 Aug;45(8):C-4. PubMed PMID: 1500357. 2. Hu MK, Yang FC, Chou CC, Yen MH. Synthesis and evaluation of backbone/amide-modified analogs of leualacin. Bioorg Med Chem Lett. 1999 Feb 22;9(4):563-8. PubMed PMID: 10098664. 3. Hamano K, Kinoshita M, Tanzawa K, Yoda K, Ohki Y, Nakamura T, Kinoshita T. Leualacin, a novel calcium blocker from Hapsidospora irregularis. II. Structure determination. J Antibiot (Tokyo). 1992 Jun;45(6):906-13. Erratum in: J Antibiot (Tokyo) 1992 Aug;45(8):C-4. PubMed PMID: 1500358. 4. Zhang S, Qiu Y, Kakule TB, Lu Z, Xu F, Lamb JG, Reilly CA, Zheng Y, Sham SW, Wang W, Xuan L, Schmidt EW, Zhan J. Identification of Cyclic Depsipeptides and Their Dedicated Synthetase from Hapsidospora irregularis. J Nat Prod. 2017 Feb 24;80(2):363-370. doi: 10.1021/acs.jnatprod.6b00808. Epub 2017 Jan 20. PubMed PMID: 28106998; PubMed Central PMCID: PMC5975237.