TargetMol

Liarozole fumarate

Product Code:
 
TAR-T25716
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T25716-5mg5mg£850.00
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Further Information

Bioactivity:
Liarozole fumarate is used as a retinoic acid metabolism blocking agent (RAMBA) and an aromatase inhibitor.
CAS:
145858-52-2
Formula:
C46H38Cl2N8O12
Molecular Weight:
965.75
Purity:
0.98
SMILES:
OC(=O)C=CC(O)=O.OC(=O)C=CC(O)=O.OC(=O)C=CC(O)=O.Clc1cccc(c1)C(c1ccc2nc[nH]c2c1)n1ccnc1.Clc1cccc(c1)C(c1ccc2nc[nH]c2c1)n1ccnc1

References

1. Goss PE, Oza A, Goel R, Nabholtz JM, De Coster R, Bruynseels J, Reid C, Wadden N, Crump M, Tye LM. Liarozole fumarate (R85246): a novel imidazole in the treatment of receptor positive postmenopausal metastatic breast cancer. Breast Cancer Res Treat. 2000 Jan;59(1):55-68. PubMed PMID: 10752680. 2. Van Wauwe J, Coene MC, Cools W, Goossens J, Lauwers W, Le Jeune L, Van Hove C, Van Nyen G. Liarozole fumarate inhibits the metabolism of 4-keto-all-trans-retinoic acid. Biochem Pharmacol. 1994 Feb 11;47(4):737-41. PubMed PMID: 8129749. 3. Vahlquist A, Blockhuys S, Steijlen P, van Rossem K, Didona B, Blanco D, Traupe H. Oral liarozole in the treatment of patients with moderate/severe lamellar ichthyosis: results of a randomized, double-blind, multinational, placebo-controlled phase II/III trial. Br J Dermatol. 2014 Jan;170(1):173-81. doi: 10.1111/bjd.12626. PubMed PMID: 24102348; PubMed Central PMCID: PMC4232915. 4. Goss PE, Strasser K, Marques R, Clemons M, Oza A, Goel R, Blackstein M, Kaizer L, Sterns EE, Nabholtz JM, De Coster R, Crump M, Abdolell M, Qi S. Liarozole fumarate (R85246): in the treatment of ER negative, tamoxifen refractory or chemotherapy resistant postmenopausal metastatic breast cancer. Breast Cancer Res Treat. 2000 Nov;64(2):177-88. PubMed PMID: 11194453.