TargetMol

Lifarizine methanesulfonate

Product Code:
 
TAR-T25722
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T25722-5mg5mg£850.00
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TAR-T25722-50mg50mg£1,661.00
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Quantity:
TAR-T25722-100mg100mg£2,079.00
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Further Information

Bioactivity:
Lifarizine methanesulfonate is a modulator of sodium-calcium channel that reduces ischemic brain damage.
CAS:
130565-83-2
Formula:
C30H36N4O3S
Molecular Weight:
532.7
Purity:
0.98
SMILES:
CS(O)(=O)=O.Cc1[nH]c(nc1CN1CCN(CC1)C(c1ccccc1)c1ccccc1)-c1ccc(C)cc1

References

1. Brown NA, Kemp JA, Seabrook GR. Block of human voltage-sensitive Na+ currents in differentiated SH-SY5Y cells by lifarizine. Br J Pharmacol. 1994 Oct;113(2):600-6. PubMed PMID: 7834213; PubMed Central PMCID: PMC1510106. 2. Budd DC, May GR, Nicholls DG, McCormack JG. Inhibition by lifarizine of intracellular Ca2+ rises and glutamate exocytosis in depolarized rat cerebrocortical synaptosomes and cultured neurones. Br J Pharmacol. 1996 May;118(1):162-6. PubMed PMID: 8733590; PubMed Central PMCID: PMC1909495. 3. MacKinnon AC, Wyatt KM, McGivern JG, Sheridan RD, Brown CM. [3H]-lifarizine, a high affinity probe for inactivated sodium channels. Br J Pharmacol. 1995 Jul;115(6):1103-9. PubMed PMID: 7582509; PubMed Central PMCID: PMC1908993. 4. McBean DE, Winters V, Wilson AD, Oswald CB, Alps BJ, Armstrong JM. Neuroprotective efficacy of lifarizine (RS-87476) in a simplified rat survival model of 2 vessel occlusion. Br J Pharmacol. 1995 Dec;116(8):3093-8. PubMed PMID: 8719782; PubMed Central PMCID: PMC1909165.