TargetMol

MDL-101146, (R)-

Product Code:
 
TAR-T25784
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T25784-5mg5mg£1,010.00
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TAR-T25784-50mg50mg£1,982.00
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Quantity:
TAR-T25784-100mg100mg£2,560.00
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This product comes from: United States.
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  • Further Information
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Further Information

Bioactivity:
MDL-101146, (R)- is an effective orally active inhibitor of human neutrophil elastase.
CAS:
163660-53-5
Formula:
C29H37F5N4O6
Molecular Weight:
632.629
Purity:
0.98
SMILES:
CC(C)[C@H](NC(=O)c1ccc(cc1)C(=O)N1CCOCC1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(C)C)C(=O)C(F)(F)C(F)(F)F

References

1. Durham SL, Hare CM, Angelastro MR, Burkhart JP, Koehl JR, Marquart AL, Mehdi S, Peet NP, Janusz MJ. Pharmacology of N-[4-(4-morpholinylcarbonyl)benzoyl]-L-valyl-N- [3,3,4,4,4-pentafluoro-1-(1-methylethyl)-2-oxobutyl]-L-prolinamide (MDL 101,146): a potent orally active inhibitor of human neutrophil elastase. J Pharmacol Exp Ther. 1994 Jul;270(1):185-91. Erratum in: J Pharmacol Exp Ther 1994 Dec;271(3):1720. PubMed PMID: 8035315. 2. Janusz MJ, Durham SL. Inhibition of cartilage degradation in rat collagen-induced arthritis but not adjuvant arthritis by the neutrophil elastase inhibitor MDL 101,146. Inflamm Res. 1997 Dec;46(12):503-8. PubMed PMID: 9459081. 3. Goodarzi M, Bora A, Borota A, Funar-Timofei S, Avram S, Heyden YV. Modeling of 2-pyridin-3-yl-benzo[d][1,3]oxazin-4-one derivatives by several conformational searching tools and molecular docking. Curr Pharm Des. 2013;19(12):2194-203. PubMed PMID: 23016845.