TargetMol

RFI-641

Product Code:
 
TAR-T26068
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T26068-5mg5mg£850.00
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Further Information

Bioactivity:
RFI-641 is a dendrimer-like compound with anti-RSV properties and is effective in vitro and in vivo activity.
CAS:
197366-24-8
Formula:
C58H60N24Na2O22S6
Molecular Weight:
1683.6
Purity:
0.98
SMILES:
[Na+].[Na+].NC(=O)CNC(=O)CNS(=O)(=O)c1cccc(Nc2nc(Nc3cccc(c3)S(=O)(=O)NCC(=O)NCC(N)=O)nc(Nc3ccc(-c4ccc(Nc5nc(Nc6cccc(c6)S(=O)(=O)NCC(=O)NCC(N)=O)nc(Nc6cccc(c6)S(=O)(=O)NCC(=O)NCC(N)=O)n5)cc4S([O-])(=O)=O)c(c3)S([O-])(=O)=O)n2)c1

References

1. Nikitenko AA, Raifeld YE, Wang TZ. The discovery of RFI-641 as a potent and selective inhibitor of the respiratory syncytial virus. Bioorg Med Chem Lett. 2001 Apr 23;11(8):1041-4. PubMed PMID: 11327584. 2. Huntley CC, Weiss WJ, Gazumyan A, Buklan A, Feld B, Hu W, Jones TR, Murphy T, Nikitenko AA, O'Hara B, Prince G, Quartuccio S, Raifeld YE, Wyde P, O'Connell JF. RFI-641, a potent respiratory syncytial virus inhibitor. Antimicrob Agents Chemother. 2002 Mar;46(3):841-7. PubMed PMID: 11850270; PubMed Central PMCID: PMC127488. 3. Weiss WJ, Murphy T, Lynch ME, Frye J, Buklan A, Gray B, Lenoy E, Mitelman S, O'Connell J, Quartuccio S, Huntley C. Inhalation efficacy of RFI-641 in an African green monkey model of RSV infection. J Med Primatol. 2003 Apr;32(2):82-8. PubMed PMID: 12823630. 4. Razinkov V, Gazumyan A, Nikitenko A, Ellestad G, Krishnamurthy G. RFI-641 inhibits entry of respiratory syncytial virus via interactions with fusion protein. Chem Biol. 2001 Jul;8(7):645-59. PubMed PMID: 11451666.