SB-217452

Product Code:

TAR-T26178

Product Group:

Inhibitors and Activators

Supplier:

TargetMol

Regulatory Status:

RUO

Shipping:

cool pack

Storage:

-20℃

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Code	Size	Price

TAR-T26178-5mg

5mg

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Further Information

Bioactivity:

SB-217452 is a potent seryl tRNA synthetase inhibitor isolated from Streptomyces.

CAS:

93301-58-7

Formula:

C16H24N6O9S

Molecular Weight:

476.46

Purity:

0.98

SMILES:

Cn(/C(ccn1[C@H]2[C@H](O)[C@@H](O)[C@@H]([C@@H](O)[C@@H](NC([C@@H](N)CO)=O)C(O)=O)S2)=N/C(N)=O)c1=O

Documents

References

1. Kim JY, Carlson BA, Xu XM, Zeng Y, Chen S, Gladyshev VN, Lee BJ, Hatfield DL. Inhibition of selenocysteine tRNA[Ser]Sec aminoacylation provides evidence that aminoacylation is required for regulatory methylation of this tRNA. Biochem Biophys Res Commun. 2011 Jun 17;409(4):814-9. doi: 10.1016/j.bbrc.2011.05.096. Epub 2011 May 23. PubMed PMID: 21624347; PubMed Central PMCID: PMC3124823. 2. Zeng Y, Roy H, Patil PB, Ibba M, Chen S. Characterization of two seryl-tRNA synthetases in albomycin-producing Streptomyces sp. strain ATCC 700974. Antimicrob Agents Chemother. 2009 Nov;53(11):4619-27. doi: 10.1128/AAC.00782-09. Epub 2009 Aug 31. PubMed PMID: 19721072; PubMed Central PMCID: PMC2772349. 3. Stefanska AL, Fulston M, Houge-Frydrych CS, Jones JJ, Warr SR. A potent seryl tRNA synthetase inhibitor SB-217452 isolated from a Streptomyces species. J Antibiot (Tokyo). 2000 Dec;53(12):1346-53. PubMed PMID: 11217799.