TargetMol

YH16899

Product Code:
 
TAR-T26342
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T26342-5mg5mg£850.00
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Quantity:
TAR-T26342-50mg50mg£1,661.00
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Quantity:
TAR-T26342-100mg100mg£2,079.00
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This product comes from: United States.
Typical lead time: 10-14 working days.
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Further Information

Bioactivity:
YH16899 is a KRS-67LR interaction inhibitor by directly blocking the association between KRS and 67LR, suppressing the dynamic movement of the N-terminal extension of KRS and reducing membrane localization of KRS.
CAS:
1428623-14-6
Formula:
C19H13F5N2O3S
Molecular Weight:
444.38
Purity:
0.98
SMILES:
CCC(C(O)=O)n1c2cc(F)c(F)cc2sc1=N/C(=O)c1cccc(c1)C(F)(F)F

References

1. Cho HY, Ul Mushtaq A, Lee JY, Kim DG, Seok MS, Jang M, Han BW, Kim S, Jeon YH. Characterization of the interaction between lysyl-tRNA synthetase and laminin receptor by NMR. FEBS Lett. 2014 Aug 25;588(17):2851-8. doi: 10.1016/j.febslet.2014.06.048. Epub 2014 Jun 28. PubMed PMID: 24983501. 2. Kim DG, Lee JY, Kwon NH, Fang P, Zhang Q, Wang J, Young NL, Guo M, Cho HY, Mushtaq AU, Jeon YH, Choi JW, Han JM, Kang HW, Joo JE, Hur Y, Kang W, Yang H, Nam DH, Lee MS, Lee JW, Kim ES, Moon A, Kim K, Kim D, Kang EJ, Moon Y, Rhee KH, Han BW, Yang JS, Han G, Yang WS, Lee C, Wang MW, Kim S. Chemical inhibition of prometastatic lysyl-tRNA synthetase-laminin receptor interaction. Nat Chem Biol. 2014 Jan;10(1):29-34. doi: 10.1038/nchembio.1381. Epub 2013 Nov 10. PubMed PMID: 24212136; PubMed Central PMCID: PMC4021855.