TargetMol

AK301

Product Code:
 
TAR-T26585
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T26585-1mg1mg£352.00
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TAR-T26585-5mg5mg£736.00
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TAR-T26585-10mg10mg£978.00
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TAR-T26585-25mg25mg£1,348.00
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TAR-T26585-50mg50mg£1,661.00
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TAR-T26585-100mg100mg£2,079.00
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This product comes from: United States.
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Further Information

Bioactivity:
AK301 is a potent and selective inhibitor of tubulin polymerization and an effective sensitizer of cancer cells to apoptotic ligands (EC50 < 200 nM). Colon cancer cells arrested in mitosis with AK301 readily underwent a p53-dependent apoptosis following compound withdrawal and arrest release.
CAS:
314022-97-4
Formula:
C19H21ClN2O2
Molecular Weight:
344.84
Pathway:
Apoptosis|Cytoskeletal Signaling
Purity:
0.98
SMILES:
CCOc1ccccc1C(=O)N1CCN(CC1)c1cccc(Cl)c1
Target:
Microtubule Associated|Apoptosis

References

1. Chopra A, Bond MJ, Bleiler M, Yeagley M, Wright D, Giardina C. Efficient Activation of Apoptotic Signaling during Mitotic Arrest with AK301. PLoS One. 2016 Apr 20;11(4):e0153818. doi: 10.1371/journal.pone.0153818. PubMed PMID: 27097159; PubMed Central PMCID: PMC4838221. 2. Chopra A, Anderson A, Giardina C. Novel piperazine-based compounds inhibit microtubule dynamics and sensitize colon cancer cells to tumor necrosis factor-induced apoptosis. J Biol Chem. 2014 Jan 31;289(5):2978-91. doi: 10.1074/jbc.M113.499319. PubMed PMID: 24338023; PubMed Central PMCID: PMC3908429.