TargetMol

CGP-54626 free base

Product Code:
 
TAR-T26998
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T26998-5mg5mg£1,171.00
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Quantity:
TAR-T26998-50mg50mg£2,303.00
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Quantity:
TAR-T26998-100mg100mg£3,042.00
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.
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This product comes from: United States.
Typical lead time: 10-14 working days.
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  • Further Information
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Further Information

Bioactivity:
CGP-54626 is a selective antagonist of the GABAB receptor (IC50 = 4 nM ).
CAS:
149936-58-3
Formula:
C18H28Cl2NO3P
Molecular Weight:
408.3
Purity:
0.98
SMILES:
C[C@H](NC[C@H](O)CP(O)(=O)CC1CCCCC1)c1ccc(Cl)c(Cl)c1

References

1. Wood MD, Murkitt KL, Rice SQ, Testa T, Punia PK, Stammers M, Jenkins O, Elshourbagy NA, Shabon U, Taylor SJ, Gager TL, Minton J, Hirst WD, Price GW, Pangalos M. The human GABA(B1b) and GABA(B2) heterodimeric recombinant receptor shows low sensitivity to phaclofen and saclofen. Br J Pharmacol. 2000 Nov;131(6):1050-4. PubMed PMID: 11082110; PubMed Central PMCID: PMC1572438. 2. Schwarz DA, Barry G, Eliasof SD, Petroski RE, Conlon PJ, Maki RA. Characterization of gamma-aminobutyric acid receptor GABAB(1e), a GABAB(1) splice variant encoding a truncated receptor. J Biol Chem. 2000 Oct 13;275(41):32174-81. Erratum in: J Biol Chem 2001 Mar 23;276(12):9582. PubMed PMID: 10906333. 3. Hashimoto T, Kuriyama K. In vivo evidence that GABA(B) receptors are negatively coupled to adenylate cyclase in rat striatum. J Neurochem. 1997 Jul;69(1):365-70. PubMed PMID: 9202330.