TargetMol

IWP-2

Product Code:
 
TAR-T2702
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T2702-5mg5mg£105.00
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Quantity:
TAR-T2702-10mg10mg£119.00
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Quantity:
TAR-T2702-25mg25mg£161.00
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Quantity:
TAR-T2702-50mg50mg£239.00
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Quantity:
TAR-T2702-100mg100mg£324.00
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Quantity:
TAR-T2702-200mg200mg£450.00
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Quantity:
TAR-T2702-500mg500mg£694.00
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Quantity:
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This product comes from: United States.
Typical lead time: 10-14 working days.
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Further Information

Bioactivity:
IWP-2, an inhibitor of Wnt processing and secretion (IC50=27 nM) in a cell-free assay, selectively blocks Porcn-mediated Wnt palmitoylation.
CAS:
686770-61-6
Formula:
C22H18N4O2S3
Molecular Weight:
466.59
Pathway:
Metabolism; Cytoskeletal Signaling; Stem Cells
Purity:
0.9976
SMILES:
Cc1ccc2nc(NC(=O)CSc3nc4CCSc4c(=O)n3-c3ccccc3)sc2c1
Target:
Casein Kinase; Wnt/beta-catenin; Porcupine

References

1. Chen B, et al. Nat Chem Biol, 2009, 5(2), 100-107. 2. Maiti G, et al. The Wingless homolog Wnt5a stimulates phagocytosis but not bacterial killing. Proc Natl Acad Sci U S A. 2012 Oct 9;109(41):16600-5. 3. Liu JD, et al. Wnt/Glycogen Synthase Kinase 3?/?-catenin Signaling Activation Mediated Sevoflurane Preconditioning-induced Cardioprotection. Chin Med J (Engl). 2015 Sep 5;128(17):2346-53.