TargetMol

DBPR-110

Product Code:
 
TAR-T27125
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T27125-5mg5mg£850.00
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  • Further Information
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Further Information

Bioactivity:
DBPR-110 is a nonstructural protein 5A (NS5A) inhibitor. DBPR-110 reduced the reporter expression of the HCV1b replicon with a EC(50) and a selective index value of 3.9 ? 0.9 pM and >12,800,000, respectively. DBPR-110 reduced HCV2a replicon activity with an EC(50) and a selective index value of 228.8 ? 98.4 pM and >173,130, respectively.
CAS:
1310694-75-7
Formula:
C50H48N6O4S2
Molecular Weight:
861.09
Purity:
0.98
SMILES:
O=C(NC(C(=O)N1CCCC1c1ncc(s1)-c1ccc(cc1)-c1ccc(cc1)-c1cnc(s1)C1CCCN1C(=O)C(NC(=O)C1CC1)c1ccccc1)c1ccccc1)C1CC1

References

1. Lin HM, Wang JC, Hu HS, Wu PS, Wang WH, Wu SY, Yang CC, Yeh TK, Hsu TA, Jiaang WT, Chao YS, Chern JH, Yueh A. Resistance studies of a dithiazol analogue, DBPR110, as a potential hepatitis C virus NS5A inhibitor in replicon systems. Antimicrob Agents Chemother. 2013 Feb;57(2):723-33. doi: 10.1128/AAC.01403-12. PubMed PMID: 23165461; PubMed Central PMCID: PMC3553732.