TargetMol

DS-8587

Product Code:
 
TAR-T27211
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T27211-5mg5mg£2,376.00
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TAR-T27211-50mg50mg£4,713.00
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Quantity:
TAR-T27211-100mg100mg£6,657.00
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  • Further Information
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Further Information

Bioactivity:
DS-8587 is a DNA topoisomerase inhibitor. DS-8587 exhibits potent antibacterial activity against quinolone-resistant A. baumannii isolates that harbor mutations in quinolone resistance-determining regions. DS-8587 significantly reduces the number of viable bacteria in a murine model of F. necrophorum-induced liver abscess. In the presence of the efflux pump inhibitor 1-(1-napthylmethyl)-piperazine, no significant changes were observed in the MIC for DS-8587.
CAS:
1356918-39-2
Formula:
C21H27ClF3N3O5
Molecular Weight:
493.91
Purity:
0.98
SMILES:
O.O.Cl.Cc1c(N2C[C@]3(N)CCC[C@]3(F)C2)c(F)cc2c1n(cc(C(O)=O)c2=O)[C@@H]1C[C@@H]1F

References

1. Nagaoka K, Yanagihara K, Morinaga Y, Kurosaka Y, Hoshino K, Kohno S. In vivo antianaerobe activity of DS-8587, a new fluoroquinolone, against Fusobacterium necrophorum in a mouse model. J Infect Chemother. 2017 Mar;23(3):131-135. doi: 10.1016/j.jiac.2016.09.007. PubMed PMID: 28109739. 2. Higuchi S, Shikata M, Chiba M, Hoshino K, Gotoh N. Characteristics of antibiotic resistance and sequence type of Acinetobacter baumannii clinical isolates in Japan and the antibacterial activity of DS-8587. J Infect Chemother. 2014 Apr;20(4):256-61. doi: 10.1016/j.jiac.2013.12.001. PubMed PMID: 24709045. 3. Higuchi S, Kurosaka Y, Uoyama S, Yoshida K, Chiba M, Ishii C, Fujikawa K, Karibe Y, Hoshino K. Anti-multidrug-resistant Acinetobacter baumannii activity of DS-8587: In vitro activity and in vivo efficacy in a murine calf muscle infection model. J Infect Chemother. 2014 May;20(5):312-6. doi: 10.1016/j.jiac.2014.01.011. PubMed PMID: 24594453. 4. Higuchi S, Onodera Y, Chiba M, Hoshino K, Gotoh N. Potent in vitro antibacterial activity of DS-8587, a novel broad-spectrum quinolone, against Acinetobacter baumannii. Antimicrob Agents Chemother. 2013 Apr;57(4):1978-81. doi: 10.1128/AAC.02374-12. PubMed PMID: 23380726; PubMed Central PMCID: PMC3623304.