TargetMol

FIIN-4

Product Code:
 
TAR-T27319
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T27319-1mg1mg£335.00
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Quantity:
TAR-T27319-5mg5mg£711.00
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TAR-T27319-10mg10mg£946.00
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TAR-T27319-25mg25mg£1,396.00
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Quantity:
TAR-T27319-50mg50mg£1,862.00
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Quantity:
TAR-T27319-100mg100mg£2,424.00
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Quantity:
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Further Information

Bioactivity:
FIIN-4 is a first-in-class covalent inhibitor of FGFR (Fibroblast Growth Factor Receptor) that inhibits metastatic breast cancer. FIIN-4 effectively blocks 3D metastatic outgrowth. In vivo application of FIIN-4 potently inhibited the growth of metastatic, patient-derived breast cancer xenografts and murine-derived metastases growing within the pulmonary microenvironment.
CAS:
2093088-81-2
Formula:
C35H38N8O4
Molecular Weight:
634.741
Pathway:
Angiogenesis|Tyrosine Kinase/Adaptors
Purity:
0.98
SMILES:
COc1cc(OC)cc(c1)N1Cc2cnc(Nc3ccc(cc3)N3CCN(C)CC3)nc2N(Cc2cccc(NC(=O)C=C)c2)C1=O
Target:
FGFR

References

1. Brown WS, Tan L, Smith A, Gray NS, Wendt MK. Covalent Targeting of Fibroblast Growth Factor Receptor Inhibits Metastatic Breast Cancer. Mol Cancer Ther. 2016 Sep;15(9):2096-106. doi: 10.1158/1535-7163.MCT-16-0136. Epub 2016 Jul 1. PubMed PMID: 27371729; PubMed Central PMCID: PMC5010989.