TargetMol

ITH-12575

Product Code:
 
TAR-T27639
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T27639-5mg5mg£850.00
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TAR-T27639-50mg50mg£1,661.00
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Quantity:
TAR-T27639-100mg100mg£2,079.00
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This product comes from: United States.
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Further Information

Bioactivity:
ITH-12575 is an inhibitor of Mitochondrial Na+/Ca2+ exchange (mNCX). ITH12575 reduces Ca(2+) influx through CALHM1 at low micromolar concentrations.
CAS:
1802013-08-6
Formula:
C18H18ClNOS
Molecular Weight:
331.86
Purity:
0.98
SMILES:
CC(C)c1ccccc1C1SCC(=O)Nc2ccc(Cl)cc12

References

1. Moreno-Ortega AJ, Mart?nez-Sanz FJ, Lajar?n-Cuesta R, de Los Rios C, Cano-Abad MF. Benzothiazepine CGP37157 and its 2'-isopropyl analogue modulate Ca?? entry through CALHM1. Neuropharmacology. 2015 Aug;95:503-10. doi: 10.1016/j.neuropharm.2015.02.016. PubMed PMID: 25908402. 2. Mart?nez-Sanz FJ, Lajar?n-Cuesta R, Gonz?lez-Lafuente L, Moreno-Ortega AJ, Punz?n E, Cano-Abad MF, de los R?os C. Neuroprotective profile of pyridothiazepines with blocking activity of the mitochondrial Na(+)/Ca(2+) exchanger. Eur J Med Chem. 2016 Feb 15;109:114-23. doi: 10.1016/j.ejmech.2015.12.043. PubMed PMID: 26774037. 3. Mart?nez-Sanz FJ, Lajar?n-Cuesta R, Moreno-Ortega AJ, Gonz?lez-Lafuente L, Fern?ndez-Morales JC, L?pez-Arribas R, Cano-Abad MF, de los R?os C. Benzothiazepine CGP37157 Analogues Exert Cytoprotection in Various in Vitro Models of Neurodegeneration. ACS Chem Neurosci. 2015 Sep 16;6(9):1626-36. doi: 10.1021/acschemneuro.5b00161. PubMed PMID: 26192029.