TargetMol

J-113397

Product Code:
 
TAR-T27649
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T27649-5mg5mg£1,251.00
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TAR-T27649-50mg50mg£2,464.00
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Quantity:
TAR-T27649-100mg100mg£3,283.00
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This product comes from: United States.
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Further Information

Bioactivity:
J-113397 is a potent and selective NOP receptor antagonist (IC50 = 2.3 nM).
CAS:
256640-45-6
Formula:
C24H37N3O2
Molecular Weight:
399.579
Purity:
0.98
SMILES:
CCn1c2ccccc2n([C@@H]2CCN(CC3CCCCCCC3)C[C@H]2CO)c1=O

References

1. Scoto GM, Aric? G, Ronsisvalle S, Parenti C. Effects of intraplantar nocistatin and (?)-J 113397 injections on nociceptive behavior in a rat model of inflammation. Pharmacol Biochem Behav. 2012 Jan;100(3):639-44. doi: 10.1016/j.pbb.2011.11.007. PubMed PMID: 22120202. 2. Visanji NP, de Bie RM, Johnston TH, McCreary AC, Brotchie JM, Fox SH. The nociceptin/orphanin FQ (NOP) receptor antagonist J-113397 enhances the effects of levodopa in the MPTP-lesioned nonhuman primate model of Parkinson's disease. Mov Disord. 2008 Oct 15;23(13):1922-5. doi: 10.1002/mds.22086. PubMed PMID: 18759357. 3. Smith ED, Ariane Vinson N, Zhong D, Berrang BD, Catanzaro JL, Thomas JB, Navarro HA, Gilmour BP, Deschamps J, Carroll FI. A new synthesis of the ORL-1 antagonist 1-[(3R,4R)-1-cyclooctylmethyl-3-hydroxymethyl-4-piperidinyl]-3-ethyl-1,3-dihydro- 2H-benzimidazol-2-one (J-113397) and activity in a calcium mobilization assay. Bioorg Med Chem. 2008 Jan 15;16(2):822-9. PubMed PMID: 17976996; PubMed Central PMCID: PMC2323199. 4. Marti M, Trapella C, Viaro R, Morari M. The nociceptin/orphanin FQ receptor antagonist J-113397 and L-DOPA additively attenuate experimental parkinsonism through overinhibition of the nigrothalamic pathway. J Neurosci. 2007 Feb 7;27(6):1297-307. PubMed PMID: 17287504.