TargetMol

Megazol

Product Code:
 
TAR-T28011
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T28011-5mg5mg£850.00
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Quantity:
TAR-T28011-50mg50mg£1,661.00
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Quantity:
TAR-T28011-100mg100mg£2,079.00
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This product comes from: United States.
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Further Information

Bioactivity:
Megazol is a nitroimidazole based drug that cures some protozoan infections. A study of nitroimidazoles found the drug extremely effective against T. cruzi and T. brucei which cause Chagas disease and African sleeping sickness, respectively.
CAS:
19622-55-0
Formula:
C6H6N6O2S
Molecular Weight:
226.21
Purity:
0.98
SMILES:
Cn1c(ncc1[N+]([O-])=O)-c1nnc(N)s1

References

1. Carvalho AS, Salom?o K, Castro SL, Conde TR, Zamith HP, Caffarena ER, Hall BS, Wilkinson SR, Boechat N. Megazol and its bioisostere 4H-1,2,4-triazole: comparing the trypanocidal, cytotoxic and genotoxic activities and their in vitro and in silico interactions with the Trypanosoma brucei nitroreductase enzyme. Mem Inst Oswaldo Cruz. 2014 Jun;109(3):315-23. Epub 2014 Mar 18. PubMed PMID: 24676659; PubMed Central PMCID: PMC4131783. 2. Salom?o K, de Souza EM, Carvalho SA, da Silva EF, Fraga CA, Barbosa HS, de Castro SL. In vitro and in vivo activities of 1,3,4-thiadiazole-2-arylhydrazone derivatives of megazol against Trypanosoma cruzi. Antimicrob Agents Chemother. 2010 May;54(5):2023-31. doi: 10.1128/AAC.01241-09. Epub 2010 Mar 15. PubMed PMID: 20231395; PubMed Central PMCID: PMC2863677. 3. Riente RR, Souza VP, Carvalho SA, Kaiser M, Brun R, da Silva EF. Leishmanicidal activity of new megazol derivatives. Med Chem. 2009 Jul;5(4):392-7. PubMed PMID: 19689398. 4. Carvalho AS, Menna-Barreto RF, Romeiro NC, de Castro SL, Boechat N. Design, synthesis and activity against Trypanosoma cruzi of azaheterocyclic analogs of megazol. Med Chem. 2007 Sep;3(5):460-5. PubMed PMID: 17897071.