TargetMol

Mequitamium iodide

Product Code:
 
TAR-T28015
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T28015-5mg5mg£850.00
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TAR-T28015-50mg50mg£1,661.00
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TAR-T28015-100mg100mg£2,079.00
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Further Information

Bioactivity:
Mequitamium iodide is a platelet activating factor (PAF) inhibitor. Mequitamium inhibits PAF-acether induced platelet aggregation and bronchoconstriction. Mequitamium is capable of inhibiting platelet-mediated effects of PAF by interfering with secondary mechanisms activated by this autacoid and not by direct antagonism of PAF at receptor sites.
CAS:
101396-42-3
Formula:
C21H25IN2S
Molecular Weight:
464.41
Purity:
0.98
SMILES:
[I-].C[N+]12CCC(CC1)C(CN1c3ccccc3Sc3ccccc13)C2

References

1. Evangelista S, Boni P, Castellucci A, Perretti F, Pretolani M, Joseph D, Renzetti AR, Subissi A, Manzini S. Antihistaminic and antiallergic properties of dextro-mequitamium iodide in upper and lower guinea pig airways: comparison with azelastine. Gen Pharmacol. 1998 Apr;30(4):513-9. PubMed PMID: 9522168. 2. Di Bugno C, Dapporto P, Giorgi R, Manzini S, Paoli P, Subissi A, Arcamone F. Absolute configuration and biological activity of mequitamium iodide enantiomers. Chirality. 1994;6(5):382-8. PubMed PMID: 8068497. 3. Abelli L, Nappi F, Subissi A, Manzini S, Giachetti A. Effect of mequitamium iodide (LG 30435) on airway microvascular leakage in the guinea-pig. Pulm Pharmacol. 1992 Jun;5(2):137-41. PubMed PMID: 1611232. 4. Renzetti AR, Barone D, Criscuoli M. High-affinity binding of mequitamium iodide (LG 30435) to muscarinic and histamine H1 receptors. Eur J Pharmacol. 1990 Jul 17;182(3):413-20. PubMed PMID: 2226618.