TargetMol

PD 130908

Product Code:
 
TAR-T28327
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T28327-5mg5mg£850.00
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TAR-T28327-50mg50mg£1,661.00
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TAR-T28327-100mg100mg£2,079.00
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Further Information

Bioactivity:
PD 130908 is an analogue of RSU 1069 with effective hypoxic cytotoxin, but less potent than RSU 1069. Toxicity toward hypoxic tumor cells in vivo is demonstrated by clamping tumors (for 60 min) following administration of PD 130908. Systemic toxicity is substantially reduced following oral drug administration. Further, doses achievable following fractionated drug treatments are sufficiently high to produce significant levels of radiosensitization.
CAS:
131505-02-7
Formula:
C8H14Br2N4O2
Molecular Weight:
358.034
Purity:
0.98
SMILES:
Br.[O-][N+](=O)c1nccn1CCCNCCBr

References

1. Cole S, Stratford IJ, Fielden EM, Adams GE, Leopold W, Elliott W, Suto M, Sebolt-Leopold J. Dual function nitroimidazoles less toxic than RSU 1069: selection of candidate drugs for clinical trial (RB 6145 and/or PD 130908. Int J Radiat Oncol Biol Phys. 1992;22(3):545-8. PubMed PMID: 1735694. 2. Sebolt-Leopold JS, Vincent PW, Beningo KA, Elliott WL, Leopold WR, Heffner TG, Wiley JN, Stier MA, Suto MJ. Pharmacologic/pharmacokinetic evaluation of emesis induced by analogs of RSU 1069 and its control by antiemetic agents. Int J Radiat Oncol Biol Phys. 1992;22(3):549-51. PubMed PMID: 1531213.