TargetMol

PF-9404C

Product Code:
 
TAR-T28391
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T28391-5mg5mg£1,251.00
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TAR-T28391-50mg50mg£2,464.00
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TAR-T28391-100mg100mg£3,283.00
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  • Further Information
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Further Information

Bioactivity:
PF-9404C is the S-S diesteroisomer of a beta adrenergic receptors blocker with vasodilatory properties. PF9404C increased the formation of cyclic GMP from 3 pmol mg?1 protein in basal conditions, to 53 pmol mg?1 protein in 10 μM in rat aorta smooth muscle cells.
CAS:
780825-97-0
Formula:
C16H25N3O9
Molecular Weight:
403.388
Purity:
0.98
SMILES:
CC(C)NC[C@H](O)COc1ccc(COC[C@H](CO[N+]([O-])=O)O[N+]([O-])=O)cc1

References

1. Villarroya M, L?pez MG, de Pascual R, Garc?a AG. Preclinical profile of PF9404C, a nitric oxide donor with beta receptor blocking properties. Cardiovasc Drug Rev. 2005 Summer;23(2):149-60. Review. PubMed PMID: 16007231. 2. Ruiz-Nu?o A, Rosado A, Garc?a AG, L?pez MG, Villarroya M. Differences in the vascular selectivity and tolerance between the NO donor/beta-blocker PF9404C and nitroglycerin. Eur J Pharmacol. 2004 Sep 13;498(1-3):203-10. PubMed PMID: 15363996. 3. Villarroya M, Herrero CJ, Ru?z-Nu?o A, de Pascual R, del Valle M, Michelena P, Grau M, Carrasco E, L?pez MG, Garc?a AG. PF9404C, a new slow NO donor with beta receptor blocking properties. Br J Pharmacol. 1999 Dec;128(8):1713-22. PubMed PMID: 10588927; PubMed Central PMCID: PMC1571821.