TargetMol

S-14671

Product Code:
 
TAR-T28641
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T28641-5mg5mg£850.00
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TAR-T28641-50mg50mg£1,661.00
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Quantity:
TAR-T28641-100mg100mg£2,079.00
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  • Further Information
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Further Information

Bioactivity:
S-14671 is a 5-HT1A receptor agonist (pKi = 9.3) with high efficacy and exceptional in vivo potency. S-14671 also acts as a 5-HT2A and 5-HT2C receptor antagonist (both are pKi = 7.8).
CAS:
135722-27-9
Formula:
C22H25N3O2S
Molecular Weight:
395.52
Purity:
0.98
SMILES:
COc1ccc2cccc(N3CCN(CCNC(=O)c4cccs4)CC3)c2c1

References

1. Schreiber R, Brocco M, de Ladonchamps BL, Millan MJ. Involvement of 5-HT1A receptors in the anxiolytic action of S 14671 in the pigeon conflict test. Pharmacol Biochem Behav. 1995 Jun-Jul;51(2-3):211-5. PubMed PMID: 7667330. 2. Schreiber R, Brocco M, Gobert A, Veiga S, Millan MJ. The potent activity of the 5-HT1A receptor agonists, S 14506 and S 14671, in the rat forced swim test is blocked by novel 5-HT1A receptor antagonists. Eur J Pharmacol. 1994 Dec 27;271(2-3):537-41. PubMed PMID: 7705455. 3. Millan MJ, Rivet JM, Canton H, Lejeune F, Bervoets K, Brocco M, Gobert A, Lefebvre de Ladonchamps B, Le Marouille-Girardon S, Verriele L, et al. S 14671: a naphtylpiperazine 5-hydroxytryptamine1A agonist of exceptional potency and high efficacy possessing antagonist activity at 5-hydroxytryptamine1C/2 receptors. J Pharmacol Exp Ther. 1992 Aug;262(2):451-63. PubMed PMID: 1323650. 4. Millan MJ, Canton H, Rivet JM, Lejeune F, Laubie M, Lavielle G. S 14671: a novel naphthylpiperazine 5-HT1A agonist of high efficacy and exceptional in vivo potency. Eur J Pharmacol. 1991 Oct 15;203(2):319-22. PubMed PMID: 1839284.