TargetMol

S39625

Product Code:
 
TAR-T28648
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T28648-5mg5mg£1,492.00
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TAR-T28648-50mg50mg£2,946.00
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Quantity:
TAR-T28648-100mg100mg£4,006.00
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Further Information

Bioactivity:
S39625, an E-ring camptothecin keto analogue, is a stable, potent, and selective topoisomerase I inhibitor without being substrates of drug efflux transporters. Nanomolar concentrations of S39625 induces intense and persistent histone gamma-H2AX. The chemical stability of the keto analogues and the ability of S39625 to produce high levels of persistent Top1-DNA cleavage complex and its potent antiproliferative activity against human cancer cell lines make S39625 a promising new anticancer drug candidate.
CAS:
536711-20-3
Formula:
C25H22N2O5
Molecular Weight:
430.46
Purity:
0.98
SMILES:
CC[C@@]1(O)C(=O)Cc2c1cc1-c3nc4cc5OCOc5cc4c(C4CCC4)c3Cn1c2=O

References

1. Takagi K, Dexheimer TS, Redon C, Sordet O, Agama K, Lavielle G, Pierr? A, Bates SE, Pommier Y. Novel E-ring camptothecin keto analogues (S38809 and S39625) are stable, potent, and selective topoisomerase I inhibitors without being substrates of drug efflux transporters. Mol Cancer Ther. 2007 Dec;6(12 Pt
1):3229-38. PubMed PMID: 18089716.