TargetMol

SU11652

Product Code:
 
TAR-T28874
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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Further Information

Bioactivity:
SU11652 is a potent cell-permeable pyrrole-indolinone compound. SU11652 acts as an ATP-competitive tyrosine kinase receptor and angiogenic inhibitor with greater selectivity for PDGFR-β (PDGFRβ, IC50 = 3 nM), Flk-1 (VEGFR2, IC50 = 27 nM), FGFR1 (IC50= 170 nM), and Kit family members (IC50=~10-500 nM) over EGFR (IC50 >20 μM). SU11652 displays anti-proliferative and pro-apoptotic properties in tumor cells.
CAS:
326914-10-7
Formula:
C22H27ClN4O2
Molecular Weight:
414.93
Purity:
0.98
SMILES:
CCN(CC)CCNC(=O)c1c(C)[nH]c(C=C2/C(=O)Nc3ccc(Cl)cc23)c1C

References

1. Vieira PS, de Arruda Campos Brasil Souza T, Honorato RV, Zanphorlin LM, Severiano KU, Rocco SA, Cavalcante de Oliveira AH, Cordeiro AT, Lopes de Oliveira PS, Oliveira de Giuseppe P, Murakami MT. Pyrrole-indolinone SU11652 targets the nucleoside diphosphate kinase from Leishmania parasites. Biochem Biophys Res Commun. 2017 May 9. pii: S0006-291X(17)30910-5. doi: 10.1016/j.bbrc.2017.05.048. [Epub ahead of print] PubMed PMID: 28499874. 2. Makihara N, Arimura K, Ago T, Tachibana M, Nishimura A, Nakamura K, Matsuo R, Wakisaka Y, Kuroda J, Sugimori H, Kamouchi M, Kitazono T. Involvement of platelet-derived growth factor receptor ? in fibrosis through extracellular matrix protein production after ischemic stroke. Exp Neurol. 2015 Feb;264:127-34. doi: 10.1016/j.expneurol.2014.12.007. Epub 2014 Dec 13. PubMed PMID: 25510317. 3. Ellegaard AM, Groth-Pedersen L, Oorschot V, Klumperman J, Kirkegaard T, Nylandsted J, J??ttel? M. Sunitinib and SU11652 inhibit acid sphingomyelinase, destabilize lysosomes, and inhibit multidrug resistance. Mol Cancer Ther. 2013 Oct;12(10):2018-30. doi: 10.1158/1535-7163.MCT-13-0084. Epub 2013 Aug 6. PubMed PMID: 23920274. 4. Guo Y, Chen Y, Xu X, Fu X, Zhao ZJ. SU11652 Inhibits tyrosine kinase activity of FLT3 and growth of MV-4-11 cells. J Hematol Oncol. 2012 Dec 6;5:72. doi: 10.1186/1756-8722-5-72. PubMed PMID: 23216927; PubMed Central PMCID: PMC3524753.