TargetMol

Sulmazole

Product Code:
 
TAR-T28881
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T28881-1mg1mg£96.00
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TAR-T28881-5mg5mg£128.00
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TAR-T28881-10mg10mg£156.00
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TAR-T28881-25mg25mg£213.00
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TAR-T28881-50mg50mg£284.00
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TAR-T28881-100mg100mg£389.00
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Quantity:
TAR-T28881-500mg500mg£830.00
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Further Information

Bioactivity:
Sulmazole is a positive inotrope sulmazole. Sulmazole inhibits the function of guanine nucleotide regulatory proteins by affecting GTP turnover. Sulmazole activates the sheep cardiac muscle sarcoplasmic reticulum calcium-release channel in the presence and absence of calcium.
CAS:
73384-60-8
Formula:
C14H13N3O2S
Molecular Weight:
287.34
Pathway:
Metabolism|Microbiology/Virology|GPCR/G Protein|Neuroscience
Purity:
0.98
SMILES:
COc1cc(ccc1-c1nc2ncccc2[nH]1)S(C)=O
Target:
Adenosine Receptor|PDE|Parasite

References

1. Hata K, Goto Y, Futaki S, Takasago T, Saeki A, Nishioka T, Suga H. Effects of milrinone and sulmazole on left ventricular mechanoenergetics in canine hearts. J Card Fail. 1996 Sep;2(3):203-13. PubMed PMID: 8891859. 2. McGarry SJ, Williams AJ. Activation of the sheep cardiac sarcoplasmic reticulum Ca(2+)-release channel by analogues of sulmazole. Br J Pharmacol. 1994 Apr;111(4):1212-20. PubMed PMID: 8032608; PubMed Central PMCID: PMC1910124. 3. Verrijk R, Vleeming W, van Rooij HH, Wemer J, Porsius AJ. Positive inotropic effects of milrinone, sulmazole and AR-L100 on isolated normal and infarcted hearts of the rat. Arch Int Pharmacodyn Ther. 1989 Jan-Feb;297:7-17. PubMed PMID: 2730243. 4. Ramkumar V, Stiles GL. The new positive inotrope sulmazole inhibits the function of guanine nucleotide regulatory proteins by affecting GTP turnover. Mol Pharmacol. 1988 Dec;34(6):761-8. PubMed PMID: 2849044.